Polychlorinated Biphenyls
Concept
Overview
subject area of
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3,3',4,4'-Tetrachlorobiphenyl oxidation in fish, bird and reptile species: relationship to cytochrome P450 1A inactivation and reactive oxygen production. Academic Article
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A model for energetics and bioaccumulation in marine mammals with applications to the right whale. Academic Article
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Ahr2-dependence of PCB126 effects on the swim bladder in relation to expression of CYP1 and cox-2 genes in developing zebrafish. Academic Article
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Altered lipid homeostasis in a PCB-resistant Atlantic killifish (Fundulus heteroclitus) population from New Bedford Harbor, MA, U.S.A. Academic Article
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Aryl hydrocarbon receptor polymorphisms and dioxin resistance in Atlantic killifish (Fundulus heteroclitus). Academic Article
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Basal and 3,3',4,4',5-pentachlorobiphenyl-induced expression of cytochrome P450 1A, 1B and 1C genes in zebrafish. Academic Article
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Biogeochemical processes governing exposure and uptake of organic pollutant compounds in aquatic organisms. Academic Article
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Brominated flame retardants and organochlorine contaminants in winter flounder, harp and hooded seals, and North Atlantic right whales from the Northwest Atlantic Ocean. Academic Article
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Changes in persistent contaminant concentration and CYP1A1 protein expression in biopsy samples from northern bottlenose whales, Hyperoodon ampullatus, following the onset of nearby oil and gas development. Academic Article
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Combination effects of AHR agonists and Wnt/?-catenin modulators in zebrafish embryos: Implications for physiological and toxicological AHR functions. Academic Article
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Consensus statement: Atlantic Coast Contaminants Workshop 2000. Academic Article
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Correlates of cytochrome P450 1A1 expression in bottlenose dolphin (Tursiops truncatus) integument biopsies. Academic Article
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Cytochrome P450 1A expression in midwater fishes: potential effects of chemical contaminants in remote oceanic zones. Academic Article
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Cytochrome P450 1A, 1B, and 1C mRNA induction patterns in three-spined stickleback exposed to a transient and a persistent inducer. Academic Article
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Cytochrome P450 1A4 and 1A5 in common cormorant (Phalacrocorax carbo): evolutionary relationships and functional implications associated with dioxin and related compounds. Academic Article
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Cytochrome P450 1D1: a novel CYP1A-related gene that is not transcriptionally activated by PCB126 or TCDD. Academic Article
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Cytochrome P4501A1 expression, polychlorinated biphenyls and hydroxylated metabolites, and adipocyte size of bottlenose dolphins from the Southeast United States. Academic Article
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Cytochromes P450 in liver of the turtle Chrysemys picta picta and the induction and partial purification of CYP1A-like proteins. Academic Article
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Delayed effects of developmental exposure to low levels of the aryl hydrocarbon receptor agonist 3,3',4,4',5-pentachlorobiphenyl (PCB126) on adult zebrafish behavior. Academic Article
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Developing tools for risk assessment in protected species: Relative potencies inferred from competitive binding of halogenated aromatic hydrocarbons to aryl hydrocarbon receptors from beluga (Delphinapterus leucas) and mouse. Academic Article
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Developmental and tissue-specific expression of AHR1, AHR2, and ARNT2 in dioxin-sensitive and -resistant populations of the marine fish Fundulus heteroclitus. Academic Article
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Differential sensitivity to pro-oxidant exposure in two populations of killifish (Fundulus heteroclitus). Academic Article
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Dose and inducer-dependent induction of cytochrome P450 1A in endothelia of the eel, including in the swimbladder rete mirabile, a model microvascular structure. Academic Article
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Early Life Exposure to Low Levels of AHR Agonist PCB126 (3,3',4,4',5-Pentachlorobiphenyl) Reprograms Gene Expression in Adult Brain. Academic Article
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Ecdysteroid receptor from the American lobster Homarus americanus: EcR/RXR isoform cloning and ligand-binding properties. Academic Article
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Effects of ortho- and non-ortho-substituted polychlorinated biphenyl congeners on the hepatic monooxygenase system in scup (Stenotomus chrysops). Academic Article
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Evaluation of gas chromatographic isotope fractionation and process contamination by carbon in compound-specific radiocarbon analysis. Academic Article
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Expression and function of ryanodine receptor related pathways in PCB tolerant Atlantic killifish (Fundulus heteroclitus) from New Bedford Harbor, MA, USA. Academic Article
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Gene knockdown by morpholino-modified oligonucleotides in the zebrafish (Danio rerio) model: applications for developmental toxicology. Academic Article
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Generalized concentration addition predicts joint effects of aryl hydrocarbon receptor agonists with partial agonists and competitive antagonists. Academic Article
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Genetic variation at aryl hydrocarbon receptor (AHR) loci in populations of Atlantic killifish (Fundulus heteroclitus) inhabiting polluted and reference habitats. Academic Article
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Gonadal feminization and halogenated environmental contaminants in common terns (Sterna hirundo): evidence that ovotestes in male embryos do not persist to the prefledgling stage. Academic Article
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Halogenated aromatic hydrocarbon-mediated porphyrin accumulation and induction of cytochrome P4501A in chicken embryo hepatocytes. Academic Article
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Hepatic metabolite profiling of polychlorinated biphenyl (PCB)-resistant and sensitive populations of Atlantic killifish (Fundulus heteroclitus). Academic Article
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Historical sources of polychlorinated biphenyls to the sediment of the New York/New Jersey Harbor. Academic Article
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Identification and expression of multiple CYP1-like and CYP3-like genes in the bivalve mollusk Mytilus edulis. Academic Article
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Identification of NF-kappaB in the marine fish Stenotomus chrysops and examination of its activation by aryl hydrocarbon receptor agonists. Academic Article
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Identification of cytochrome P450 1B-like sequences in two teleost fish species (scup, Stenotomus chrysops and plaice, Pleuronectes platessa) and in a cetacean (striped dolphin, Stenella coeruleoalba). Academic Article
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Identification of highly brominated analogues of Q1 in marine mammals. Academic Article
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Immunohistochemical localization of cytochrome P-450IA1 induced by 3,3',4,4'-tetrachlorobiphenyl and by 2,3,7,8-tetrachlorodibenzoafuran in liver and extrahepatic tissues of the teleost Stenotomus chrysops (scup). Academic Article
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Immunohistochemical localization of cytochrome P4501A induced by 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in multiple organs of northern leopard frogs, Rana pipiens. Academic Article
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Immunohistochemical localization of environmentally induced cytochrome P450IA1 in multiple organs of the marine teleost Stenotomus chrysops (Scup). Academic Article
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Importance of passive diffusion in the uptake of polychlorinated biphenyls by phagotrophic protozoa. Academic Article
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In vitro metabolism of polychlorinated biphenyl congeners by beluga whale (Delphinapterus leucas) and pilot whale (Globicephala melas) and relationship to cytochrome P450 expression. Academic Article
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Induction and post-transcriptional suppression of hepatic cytochrome P450 1A1 by 3,3',4,4'-tetrachlorobiphenyl. Academic Article
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Induction and suppression of cytochrome P450 1A by 3,3',4,4',5-pentachlorobiphenyl and its relationship to oxidative stress in the marine fish scup (Stenotomus chrysops). Academic Article
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Induction of cytochrome P-450-dependent monooxygenase systems in embryos and eleutheroembryos of the killfish Fundulus heteroclitus. Academic Article
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Induction patterns of new CYP1 genes in environmentally exposed rainbow trout. Academic Article
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Integrating Monitoring and Genetic Methods To Infer Historical Risks of PCBs and DDE to Common and Roseate Terns Nesting Near the New Bedford Harbor Superfund Site (Massachusetts, USA). Academic Article
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Invariant chlorine isotopic signatures during microbial PCB reductive dechlorination. Academic Article
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Low inducibility of CYP1A activity by polychlorinated biphenyls (PCBs) in flounder (Platichthys flesus): characterization of the Ah receptor and the role of CYP1A inhibition. Academic Article
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Marine natural products, the halogenated 1'-methyl-1,2'-bipyrroles, biomagnify in a northwestern Atlantic food web. Academic Article
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Marine protozoa produce organic matter with a high affinity for PCBs during grazing. Academic Article
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Mechanistic basis of resistance to PCBs in Atlantic tomcod from the Hudson River. Academic Article
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Metabolism of the aryl hydrocarbon receptor agonist 3,3',4,4'-tetrachlorobiphenyl by the marine fish scup (Stenotomus chrysops) in vivo and in vitro. Academic Article
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New CYP1 genes in the frog Xenopus (Silurana) tropicalis: induction patterns and effects of AHR agonists during development. Academic Article
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New cytochrome P450 1B1, 1C2 and 1D1 genes in the killifish Fundulus heteroclitus: Basal expression and response of five killifish CYP1s to the AHR agonist PCB126. Academic Article
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Organic micropollutants in marine plastics debris from the open ocean and remote and urban beaches. Academic Article
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Organohalogen contaminants and metabolites in cerebrospinal fluid and cerebellum gray matter in short-beaked common dolphins and Atlantic white-sided dolphins from the western North Atlantic. Academic Article
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Oxidative inactivation of cytochrome P-450 1A (CYP1A) stimulated by 3,3',4,4'-tetrachlorobiphenyl: production of reactive oxygen by vertebrate CYP1As. Academic Article
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PCB and hydrocarbon contamination of plankton by nets. Academic Article
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Pacific Ocean-wide profile of CYP1A1 expression, stable carbon and nitrogen isotope ratios, and organic contaminant burden in sperm whale skin biopsies. Academic Article
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Polychlorinated biphenyls in clams and oysters from New Bedford Harbor, Massachusetts, March 1978. Academic Article
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Polychlorobiphenyls in North Atlantic ocean water. Academic Article
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Radiocarbon content of synthetic and natural semi-volatile halogenated organic compounds. Academic Article
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Regulation of Ahr signaling by Nrf2 during development: Effects of Nrf2a deficiency on PCB126 embryotoxicity in zebrafish (Danio rerio). Academic Article
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Regulation of pregnane-X-receptor, CYP3A and P-glycoprotein genes in the PCB-resistant killifish (Fundulus heteroclitus) population from New Bedford Harbor. Academic Article
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Relative contributions of affinity and intrinsic efficacy to aryl hydrocarbon receptor ligand potency. Academic Article
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Role of AHR2 in the expression of novel cytochrome P450 1 family genes, cell cycle genes, and morphological defects in developing zebra fish exposed to 3,3',4,4',5-pentachlorobiphenyl or 2,3,7,8-tetrachlorodibenzo-p-dioxin. Academic Article
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Role of DNA methylation of AHR1 and AHR2 promoters in differential sensitivity to PCBs in Atlantic Killifish, Fundulus heteroclitus. Academic Article
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Role of pregnane X receptor and aryl hydrocarbon receptor in transcriptional regulation of pxr, CYP2, and CYP3 genes in developing zebrafish. Academic Article
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Serum alters the uptake and relative potencies of halogenated aromatic hydrocarbons in cell culture bioassays. Academic Article
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Simultaneous quantitation of multiple classes of organohalogen compounds in fish oils with direct sample introduction comprehensive two-dimensional gas chromatography and time-of-flight mass spectrometry. Academic Article
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Structural changes in gill DNA reveal the effects of contaminants on Puget Sound fish. Academic Article
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Structural features of cytochrome P450 1A associated with the absence of EROD activity in liver of the loricariid catfish Pterygoplichthys sp. Academic Article
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Structure elucidation and characterization of polychlorinated biphenyl carboxylic acids as major constituents of chromophoric dissolved organic matter in seawater. Academic Article
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The absence and application of stable carbon isotopic fractionation during the reductive dechlorination of polychlorinated biphenyls. Academic Article
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Transcriptomic assessment of resistance to effects of an aryl hydrocarbon receptor (AHR) agonist in embryos of Atlantic killifish (Fundulus heteroclitus) from a marine Superfund site. Academic Article
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Uncoupling of cytochrome P450 1A and stimulation of reactive oxygen species production by co-planar polychlorinated biphenyl congeners. Academic Article
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Uroporphyrin accumulation associated with cytochrome P4501A induction in fish hepatoma cells exposed to aryl hydrocarbon receptor agonists, including 2,3,7,8-tetrachlorodibenzo-p-dioxin and planar chlorobiphenyls. Academic Article