P-Selectin
Concept
Overview
subject area of
-
A 130-kDa protein on endothelial cells binds to amino acids 15-42 of the B beta chain of fibrinogen. Academic Article
-
A differential role for cell shape in neutrophil tethering and rolling on endothelial selectins under flow. Academic Article
-
A high affinity human antibody antagonist of P-selectin mediated rolling. Academic Article
-
A new role in hemostasis for the adhesion receptor P-selectin. Academic Article
-
A schiff base with mildly oxidized carbohydrate ligands stabilizes L-selectin and not P-selectin or E-selectin rolling adhesions in shear flow. Academic Article
-
ADAMTS13: a new link between thrombosis and inflammation. Academic Article
-
Activated platelets induce Weibel-Palade-body secretion and leukocyte rolling in vivo: role of P-selectin. Academic Article
-
Acute passive anti-glomerular basement membrane nephritis in P-selectin-deficient mice. Academic Article
-
Angiogenesis in P- and E-selectin-deficient mice. Academic Article
-
Antithrombotic activity of TNF-alpha. Academic Article
-
Blood cell dynamics in P-selectin-deficient mice. Academic Article
-
Characterization of a novel adhesion function blocking monoclonal antibody to rat/mouse P-selectin generated in the P-selectin-deficient mouse. Academic Article
-
Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins. Academic Article
-
Defect in regulated secretion of P-selectin affects leukocyte recruitment in von Willebrand factor-deficient mice. Academic Article
-
Defects in hemostasis in P-selectin-deficient mice. Academic Article
-
Dietary omega-3 alpha-linolenic acid does not prevent venous thrombosis in mice. Academic Article
-
Distinct cell surface ligands mediate T lymphocyte attachment and rolling on P and E selectin under physiological flow. Academic Article
-
Divergent fates of P- and E-selectins after their expression on the plasma membrane. Academic Article
-
Donor MHC and adhesion molecules in transplant arteriosclerosis. Academic Article
-
Double knockout highlights value of endothelial selectins. Academic Article
-
E and P selectins are not required for resistance to severe murine lyme arthritis. Academic Article
-
Effects of a monoclonal antibody to P-selectin on recovery of neonatal lamb hearts after cold cardioplegic ischemia. Academic Article
-
Elevated levels of homocysteine compromise blood-brain barrier integrity in mice. Academic Article
-
Elevated levels of soluble P-selectin in mice alter blood-brain barrier function, exacerbate stroke, and promote atherosclerosis. Academic Article
-
Endothelial selectins and vascular cell adhesion molecule-1 promote hematopoietic progenitor homing to bone marrow. Academic Article
-
Experimental murine acid aspiration injury is mediated by neutrophils and the alternative complement pathway. Academic Article
-
Formation of platelet strings and microthrombi in the presence of ADAMTS-13 inhibitor does not require P-selectin or beta3 integrin. Academic Article
-
Hematopoietic progenitor cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and vascular cell adhesion molecule 1. Academic Article
-
Hypoxia-induced exocytosis of endothelial cell Weibel-Palade bodies. A mechanism for rapid neutrophil recruitment after cardiac preservation. Academic Article
-
Infection-mediated early-onset periodontal disease in P/E-selectin-deficient mice. Academic Article
-
Inhibition of VEGF or TGF-{beta} signaling activates endothelium and increases leukocyte rolling. Academic Article
-
Insights into selectin function from knockout mice. Academic Article
-
Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A. Academic Article
-
Interactions of human alpha/beta and gamma/delta T lymphocyte subsets in shear flow with E-selectin and P-selectin. Academic Article
-
Interleukin 11 significantly increases plasma von Willebrand factor and factor VIII in wild type and von Willebrand disease mouse models. Academic Article
-
Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Academic Article
-
Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins. Academic Article
-
Lifetime of the P-selectin-carbohydrate bond and its response to tensile force in hydrodynamic flow. Academic Article
-
Measurement of selectin tether bond lifetimes. Academic Article
-
Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. Academic Article
-
Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment. Academic Article
-
Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta 2-integrin CD11b/CD18. Academic Article
-
New discoveries with mice mutant in endothelial and platelet selectins. Academic Article
-
Overlapping functions of E- and P-selectin in neutrophil recruitment during acute inflammation. Academic Article
-
P- and E-selectin-deficient mice are susceptible to cerebral ischemia-reperfusion injury. Academic Article
-
P- and E-selectins are required for the leukocyte recruitment, but not the tissue swelling, associated with IgE- and mast cell-dependent inflammation in mouse skin. Academic Article
-
P-Selectin and platelet clearance. Academic Article
-
P-Selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo. Academic Article
-
P-selectin and E-selectin. Distinct but overlapping leukocyte ligand specificities. Academic Article
-
P-selectin and leukocyte microparticles are associated with venous thrombogenesis. Academic Article
-
P-selectin chases a butterfly. Academic Article
-
P-selectin knockout: a mouse model for various human diseases. Academic Article
-
P-selectin mediates adhesion of platelets to neuroblastoma and small cell lung cancer. Academic Article
-
P-selectin promotes neutrophil extracellular trap formation in mice. Academic Article
-
P-selectin, L-selectin, and alpha 4 integrin have distinct roles in eosinophil tethering and arrest on vascular endothelial cells under physiological flow conditions. Academic Article
-
P-selectin, a granule membrane protein of platelets and endothelial cells, follows the regulated secretory pathway in AtT-20 cells. Academic Article
-
PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells. Academic Article
-
PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes. Academic Article
-
PADGEM, a leukocyte receptor on activated platelets. Biology and application to in vivo medical diagnostics. Academic Article
-
PADGEM-dependent adhesion of platelets to monocytes and neutrophils is mediated by a lineage-specific carbohydrate, LNF III (CD15). Academic Article
-
PSGL-1 regulates platelet P-selectin-mediated endothelial activation and shedding of P-selectin from activated platelets. Academic Article
-
Platelet P-selectin facilitates atherosclerotic lesion development. Academic Article
-
Platelet adhesion receptors do not modulate infarct volume after a photochemically induced stroke in mice. Academic Article
-
Platelet granule secretion continuously prevents intratumor hemorrhage. Academic Article
-
Platelet-endothelial interactions in inflamed mesenteric venules. Academic Article
-
Platelet-mediated lymphocyte delivery to high endothelial venules. Academic Article
-
Platelets roll on stimulated endothelium in vivo: an interaction mediated by endothelial P-selectin. Academic Article
-
Pro-coagulant state resulting from high levels of soluble P-selectin in blood. Academic Article
-
Prominent role of P-selectin in the development of advanced atherosclerosis in ApoE-deficient mice. Academic Article
-
Reduced recruitment of inflammatory cells in a contact hypersensitivity response in P-selectin-deficient mice. Academic Article
-
Remodeling of the lectin-EGF-like domain interface in P- and L-selectin increases adhesiveness and shear resistance under hydrodynamic force. Academic Article
-
Role of P-selectin cytoplasmic domain in granular targeting in vivo and in early inflammatory responses. Academic Article
-
Rolling in P-selectin-deficient mice is reduced but not eliminated in the dorsal skin. Academic Article
-
Selectin receptor-ligand bonds: Formation limited by shear rate and dissociation governed by the Bell model. Academic Article
-
Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins. Academic Article
-
The A2B adenosine receptor protects against inflammation and excessive vascular adhesion. Academic Article
-
The P-selectin, tissue factor, coagulation triad. Academic Article
-
The Weibel-Palade body: the storage granule for von Willebrand factor and P-selectin. Academic Article
-
The combined role of P- and E-selectins in atherosclerosis. Academic Article
-
The faster kinetics of L-selectin than of E-selectin and P-selectin rolling at comparable binding strength. Academic Article
-
The kinetics and shear threshold of transient and rolling interactions of L-selectin with its ligand on leukocytes. Academic Article
-
The kinetics of L-selectin tethers and the mechanics of selectin-mediated rolling. Academic Article
-
The transmembrane domain enhances granular targeting of P-selectin. Academic Article
-
Tissue factor expressed by circulating cancer cell-derived microparticles drastically increases the incidence of deep vein thrombosis in mice. Academic Article
-
Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Academic Article
-
Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates GPIbalpha shedding from platelets in vitro and in vivo. Academic Article