subject area of

• APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.  Academic Article
• ATP is required for the release of the anaphase-promoting complex/cyclosome from inhibition by the mitotic checkpoint.  Academic Article
• Affinity purification of mitotic anaphase-promoting complex/cyclosome on p13Suc1.  Academic Article
• Binding of activated cyclosome to p13(suc1). Use for affinity purification.  Academic Article
• Cyclin-specific control of ribosomal DNA segregation.  Academic Article
• Dual mode of degradation of Cdc25 A phosphatase.  Academic Article
• Elevating the level of Cdc34/Ubc3 ubiquitin-conjugating enzyme in mitosis inhibits association of CENP-E with kinetochores and blocks the metaphase alignment of chromosomes.  Academic Article
• From rabbit reticulocytes to clam oocytes: in search of the system that targets mitotic cyclins for degradation.  Academic Article
• Inhibitory factors associated with anaphase-promoting complex/cylosome in mitotic checkpoint.  Academic Article
• Limited functional redundancy and oscillation of cyclins in multinucleated Ashbya gossypii fungal cells.  Academic Article
• Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events.  Academic Article
• Mechanisms and regulation of the degradation of cyclin B.  Academic Article
• Mode of interaction of TRIP13 AAA-ATPase with the Mad2-binding protein p31comet and with mitotic checkpoint complexes.  Academic Article
• Mutual antagonism between the anaphase promoting complex and the spindle assembly checkpoint contributes to mitotic timing in Caenorhabditis elegans.  Academic Article
• Phosphorylation of Cdc20/fizzy negatively regulates the mammalian cyclosome/APC in the mitotic checkpoint.  Academic Article
• Phosphorylation of the cyclosome is required for its stimulation by Fizzy/cdc20.  Academic Article
• Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit.  Academic Article
• Protein dynamics at the kinetochore: cell cycle regulation of the metaphase to anaphase transition.  Academic Article
• Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells.  Academic Article
• Regulating the yeast kinetochore by ubiquitin-dependent degradation and Skp1p-mediated phosphorylation.  Academic Article
• Regulation of APC/C (Cdh1) ubiquitin ligase in differentiation of human embryonic stem cells.  Academic Article
• Regulation of mRNA translation during mitosis.  Academic Article
• Regulation of the action of early mitotic inhibitor 1 on the anaphase-promoting complex/cyclosome by cyclin-dependent kinases.  Academic Article
• Regulatory modules: Coupling protein stability to phopshoregulation during cell division.  Academic Article
• Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome.  Academic Article
• Role of Suc1 in the activation of the cyclosome by protein kinase Cdk1/cyclin B.  Academic Article
• Role of phosphorylation of Cdc20 in p31(comet)-stimulated disassembly of the mitotic checkpoint complex.  Academic Article
• Role of ubiquitylation of components of mitotic checkpoint complex in their dissociation from anaphase-promoting complex/cyclosome.  Academic Article
• Roles of different pools of the mitotic checkpoint complex and the mechanisms of their disassembly.  Academic Article
• Roles of the anaphase-promoting complex/cyclosome and of its activator Cdc20 in functional substrate binding.  Academic Article
• Roles of ubiquitin-mediated proteolysis in cell cycle control.  Academic Article
• Spatiotemporal regulation of the anaphase-promoting complex in mitosis.  Academic Article
• Systematic analysis of human protein complexes identifies chromosome segregation proteins.  Academic Article
• The 3F3/2 anti-phosphoepitope antibody binds the mitotically phosphorylated anaphase-promoting complex/cyclosome.  Academic Article
• The Giardia cell cycle progresses independently of the anaphase-promoting complex.  Academic Article
• The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication.  Academic Article
• The anaphase-promoting complex/cyclosome is required for anaphase progression in multinucleated Ashbya gossypii cells.  Academic Article
• The cyclin-ubiquitin ligase activity of cyclosome/APC is jointly activated by protein kinases Cdk1-cyclin B and Plk.  Academic Article
• The spindle and kinetochore-associated (Ska) complex enhances binding of the anaphase-promoting complex/cyclosome (APC/C) to chromosomes and promotes mitotic exit.  Academic Article
• The ubiquitin system for protein degradation and some of its roles in the control of the cell division cycle.  Academic Article
• Transitions regulating the timing of cytokinesis in embryonic cells.  Academic Article
• Two different mitotic checkpoint inhibitors of the anaphase-promoting complex/cyclosome antagonize the action of the activator Cdc20.  Academic Article
• Vertebrate shugoshin links sister centromere cohesion and kinetochore microtubule stability in mitosis.  Academic Article
• p31comet Promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process.  Academic Article