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Publications in VIVO

Mayor, Satyajit HHMI/HCIA Summer Institute Principal Investigator, Whitman Center


How a eukaryotic cell constructs signaling complexes (regulation of local composition) and engages in membrane traffic, in particular during endocytosis (constructing endocytic platforms) is the primary focus of my laboratory. My laboratory’s goal is to uncover physico-chemical rules and principles that govern local regulated organization of the cell membrane. This will help understand how the cell constructs functional signaling complexes and responsive endocytic platforms. To study phenomena at the cellular scale, we utilize principles from the physical sciences to frame questions about movement of molecules and organelles inside cells. We have also have developed numerous microscopy tools to study organization of cellular components, from the nanometer scale in specialized domains in cell membranes to the micron scale prevalent in mapping endocytic pathways. We study sorting properties and endocytic pathways of a variety of molecules, including membrane proteins, lipids and lipid-tethered proteins in vivo. Our studies provide a compelling picture of the cell membrane as an active composite of the lipid bilayer and a dynamic cortical actin layer beneath, wherein, dynamic actin filaments help in controlling the local composition of membranes, and shaping endocytic trafficking.

selected publications