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Publications in VIVO

Rosen, Michael Keith Whitman Center Scientist, Whitman Center


Cells are organized on length scales of angstroms to microns, and on timescales of picoseconds to hours. Organization at the shortest and longest ends of these scales is increasingly well understood through work in structural biology/biophysics and cell biology, respectively. However, the mechanisms by which the properties of individual molecules give rise to cellular architecture and function remain poorly understood. Research in the Rosen lab is focused on understanding the physical mechanisms of cell organization across scales, primarily through studies of the signaling pathways that control the actin cytoskeleton. Our work is directed toward both understanding the structure and dynamics of individual proteins and their signaling complexes, as well as discovering how and why these discrete entities produce cellular organization and activities at longer length and time scales.

selected publications