A steroid-conjugated contrast agent for magnetic resonance imaging of cell signaling. Academic Article uri icon

abstract

  • We have synthesized the first steroid hormone-MR contrast agent conjugate designed to track the cell signaling process upon binding to a gene switch system. The derivative has a high relaxivity and when tested in vitro is active as a progesterone antagonist (RU-486). By combining a transcriptional system and a noninvasive imaging technology, such as MRI, it would be a powerful tool to research the cell signaling pathway in vivo.

publication date

  • September 28, 2005