Hand-holding for retrohoming in a molecular diversity dance. Academic Article uri icon


  • In bacterial systems, adaptive protein sequence changes can be mediated by diversity-generating retroelements in a process known as retrohoming. An accessory variability determinant (Avd), together with a reverse transcriptase (RT), is critically involved in this process. In this issue of Structure, Alayyoubi and colleagues describe the structure of Avd as a basis for interactions with RT that promote retrohoming.

publication date

  • February 5, 2013