Nucleation of microtubule assembly by a gamma-tubulin-containing ring complex. Academic Article uri icon

abstract

  • The highly conserved protein gamma-tubulin is required for microtubule nucleation in vivo. When viewed in the electron microscope, a highly purified gamma-tubulin complex from Xenopus consisting of at least seven different proteins is seen to have an open ring structure. This complex acts as an active microtubule-nucleating unit which can cap the minus ends of microtubules in vitro.

publication date

  • December 7, 1995