A rapid method for production of binucleate cells. Academic Article uri icon


  • Populations of BHK-21 fibroblasts that are 90-95% binucleate can be obtained within 2-3 h by combining mitotic synchrony techniques with use of the drug cytochalasin B. Such populations are potentially useful for the study of nuclear-cytoplasmic balance and control, nuclear synchrony, and the production of tetraploid cell lines. © 1974.

publication date

  • February 1974