Integrin avidity regulation: are changes in affinity and conformation underemphasized? Academic Article uri icon

abstract

  • Integrins play critical roles in development, wound healing, immunity and cancer. Central to their function is their unique ability to modulate dynamically their adhesiveness through both affinity- and valency-based mechanisms. Recent advances have shed light on the structural basis for affinity regulation and on the signaling mechanisms responsible for both affinity and valency modes of regulation.

publication date

  • October 2003