Neuronal Ca2+ signalling takes the local route. Academic Article uri icon


  • The past year has seen several sets of experimental results demonstrate that fast, large and highly localized rises in intracellular Ca2+ concentration can occur in neurons. These results confirm previous theoretical predictions of acute spatial compartmentalization of Ca2+ signalling, and document a form of signalling that may occur whenever rapid and local signal processing is the goal. The dimensions involved present severe challenges for attempts to directly measure these signalling events.

publication date

  • June 1992