Analyses of large-scale (>750 km) ocean bottom pressure pb fields, derived from the Gravity Recovery and Climate Experiment (GRACE) and from an Estimating the Circulation & Climate of the Ocean (ECCO) state estimate, reveal enhanced interannual variability, partially connected to the Antarctic Oscillation, in regions of the Australian–Antarctic Basin and the Bellingshausen Basin, with pb magnitudes comparable to those of sea level and good correlation between the GRACE and ECCO pb series. Consistent with the theory of Gill and Niiler, the patterns of stronger pb variability are partly related to enhanced local wind curl forcing and weakened gradients in H/f, where H is ocean depth and f is the Coriolis parameter. Despite weaker H/f gradients, motions against them are sufficiently strong to play a role in balancing the local wind input. Topographic effects are as or more important than changes in f. Additionally, and contrary to the dominance of barotropic processes at subannual time scales, baroclinic effects are not negligible when balancing wind input at periods of a few years. Results highlight the emerging capability to accurately observe and estimate interannual changes in large-scale pb over the Southern Ocean, with implications for the interpretation of low-frequency variability in sea level in terms of steric height and heat content.