The circulation in the equatorial Pacific Ocean is studied in a series of numerical experiments based on an isopycnal coordinate model. The model is subject to monthly mean climatology of wind stress and surface thermohaline forcing. In response to decadal variability in the diapycnal mixing coefficient, sea surface temperature and other properties of the circulation system oscillate periodically. The strongest sea surface temperature anomaly appears in the geographic location of Niño-3 region with the amplitude on the order of 0.5°C, if the model is subject to a 30-yr sinusoidal oscillation in diapycnal mixing coefficient that varies between 0.03 × 10?4 and 0.27 × 10?4 m2 s?1. Changes in diapycnal mixing coefficient of this amplitude are within the bulk range consistent with the external mechanical energy input in the global ocean, especially when considering the great changes of tropical cyclones during the past decades. Thus, time-varying diapycnal mixing associated with changes in wind energy input into the ocean may play a nonnegligible role in decadal climate variability in the equatorial circulation and climate.