Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel. Academic Article uri icon

abstract

  • The complete amino-acid sequence of the cyclic GMP-gated channel from bovine retinal rod photoreceptors, deduced by cloning and sequencing its complementary DNA, shows that the protein contains several putative transmembrane segments, followed by a region that is similar to the cyclic GMP-binding domains of cyclic GMP-dependent protein kinase. Expression of the complementary DNA produces cyclic GMP-gated channel activity in Xenopus oocytes.

publication date

  • December 14, 1989