3-Thio-quinolinone maxi-K openers for the treatment of erectile dysfunction. Academic Article uri icon


  • A series of Maxi-K openers for the treatment of erectile dysfunction based on the 3-thio-quinolinone core is described. Significant levels of channel opening (up to 550% of control) are seen in transfected oocytes. Functional activity in rabbit corpus cavernosum tissue strips confirms the potential to effect therapy for ED, the effect being maximal for the 3-amino-2-hydroxy thiol side chain.

publication date

  • October 18, 2004

has subject area