Bigger Isn't Always Better: Cell Size and the Spindle Assembly Checkpoint. Academic Article uri icon


  • Variation in the activity of the spindle assembly checkpoint has been observed in different cell types, yet the reason for this variability remains poorly understood. Reporting in Developmental Cell, Galli and Morgan (2016) show that checkpoint activity increases during development as cell size, and the cytoplasm-to-kinetochore ratio, decreases.

publication date

  • February 8, 2016