Optimizing the Quantity/Quality Trade-Off in Connectome Inference Academic Article uri icon


  • We demonstrate a meaningful prospective power analysis for an (admittedly idealized) illustrative connectome inference task. Modeling neurons as vertices and synapses as edges in a simple random graph model, we optimize the trade-off between the number of (putative) edges identified and the accuracy of the edge identification procedure. We conclude that explicit analysis of the quantity/quality trade-off is imperative for optimal neuroscientific experimental design. In particular, more though more errorful edge identification can yield superior inferential performance.

publication date

  • October 2, 2013