selected publications
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academic article
- Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates A?, tau, immunity and lipid processing.. Nature Genetics. 51:414-430. 2019
- Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.. Nature Genetics. 49:1373-1384. 2017
- Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans.. Alzheimer's & Dementia. 13:119-129. 2017
- Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk.. Alzheimer's & Dementia. 12:233-243. 2016
- A novel Alzheimer disease locus located near the gene encoding tau protein.. Molecular Psychiatry. 21:108-117. 2016
- Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals.. JAMA Neurol. 72:1313-1323. 2015
- Rarity of the Alzheimer disease-protective APP A673T variant in the United States.. JAMA Neurol. 72:209-216. 2015
- Synaptic, transcriptional and chromatin genes disrupted in autism.. Nature Nature. 515:209-215. 2014
- Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.. JAMA Neurol. 71:1394-1404. 2014
- A framework for the interpretation of de novo mutation in human disease.. Nature Genetics. 46:944-950. 2014
- Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias.. PLoS genetics. 10:e1004606. 2014
- PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation.. Annals of Neurology. 76:379-392. 2014
- Convergence of genes and cellular pathways dysregulated in autism spectrum disorders.. American Journal of Human Genetics. 94:677-694. 2014
- Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.. PloS one. 9:e94661. 2014
- Whole exome sequencing reveals minimal differences between cell line and whole blood derived DNA.. Genomics. 102:270-277. 2013
- Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.. Nature Genetics. 45:984-994. 2013
- Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ?4,and the risk of late-onset Alzheimer disease in African Americans.. JAMA : the journal of the American Medical Association. 309:1483-1492. 2013
- Analysis of rare, exonic variation amongst subjects with autism spectrum disorders and population controls.. PLoS genetics. 9:e1003443. 2013
- Rare complete knockouts in humans: population distribution and significant role in autism spectrum disorders.. Neuron. 77:235-242. 2013
- Integrated model of de novo and inherited genetic variants yields greater power to identify risk genes.. PLoS genetics. 9:e1003671. 2013
- Individual common variants exert weak effects on the risk for autism spectrum disorders.. Human Molecular Genetics. 21:4781-4792. 2012
- Patterns and rates of exonic de novo mutations in autism spectrum disorders.. Nature Nature. 485:242-245. 2012
- A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder.. Human Genetics. 131:565-579. 2012
- Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.. Nature Genetics. 43:436-441. 2011
- Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes.. Archives of Neurology -Chigago-. 67:1473-1484. 2010
- A genome-wide scan for common alleles affecting risk for autism.. Human Molecular Genetics. 19:4072-4082. 2010
- High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility.. Molecular Psychiatry. 15:954-968. 2010
- Functional impact of global rare copy number variation in autism spectrum disorders.. Nature Nature. 466:368-372. 2010
- Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes.. PLoS genetics. 5:e1000536. 2009
- Autism genome-wide copy number variation reveals ubiquitin and neuronal genes.. Nature Nature. 459:569-573. 2009
- Common genetic variants on 5p14.1 associate with autism spectrum disorders.. Nature Nature. 459:528-533. 2009
- Mapping autism risk loci using genetic linkage and chromosomal rearrangements.. Nature Genetics. 39:319-328. 2007