selected publications
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academic article
- Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates A?, tau, immunity and lipid processing.. Nature Genetics. 51:414-430. 2019
- Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.. Nature Genetics. 49:1373-1384. 2017
- A novel Alzheimer disease locus located near the gene encoding tau protein.. Molecular Psychiatry. 21:108-117. 2016
- Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.. PloS one. 9:e94661. 2014
- Aberrant neurite outgrowth by HIV-gp120 is mediated via activation of Cdk5. Journal of NeuroVirology. 18:59-60. 2012
- Overexpression of p35 in Min6 pancreatic beta cells induces a stressed neuron-like apoptosis.. Journal of the Neurological Sciences. 299:101-107. 2010
- Cdk5-mediated phosphorylation of delta-catenin regulates its localization and GluR2-mediated synaptic activity.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30:8457-8467. 2010
- Neurofilament tail phosphorylation: identity of the RT-97 phosphoepitope and regulation in neurons by cross-talk among proline-directed kinases.. Journal of Neurochemistry. 107:35-49. 2008
- Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons.. Molecular Biology of the Cell. 18:3645-3655. 2007
- Peptides derived from Cdk5 activator p35, specifically inhibit deregulated activity of Cdk5.. Biotechnology Journal. 2:978-987. 2007
- Cdk5 Modulation of mitogen-activated protein kinase signaling regulates neuronal survival.. Molecular Biology of the Cell. 18:404-413. 2007
- Inhibition of Cdk5 Sustains Mapk (Erk1/2) Activation in Cortical Neurons and Induces Apoptosis. Molecular Biology of the Cell. 17. 2006
- Neuronal nuclear organization is controlled by cyclin-dependent kinase 5 phosphorylation of Ras Guanine nucleotide releasing factor-1.. Neuro-Signals Biological signals and receptors. 15:157-173. 2006
- A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons.. EMBO Journal. 24:209-220. 2005
- Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease.. American Journal of Pathology. 165:795-805. 2004
- p35/cyclin-dependent kinase 5 phosphorylation of ras guanine nucleotide releasing factor 2 (RasGRF2) mediates Rac-dependent Extracellular Signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in neurons.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24:4421-4431. 2004
- Neuronal cyclin-dependent kinase 5: role in nervous system function and its specific inhibition by the Cdk5 inhibitory peptide.. BBA - Protein Structure and Molecular Enzymology BBA - Proteins and Proteomics. 1697:143-153. 2004
- Cdk5 regulates axonal transport and phosphorylation of neurofilaments in cultured neurons.. Journal of cell science. 117:933-941. 2004
- p35/Cdk5 phosphorylates RasGRF2 regulating RasGRF2-mediated Rac signaling and ERK1/2 activity. Journal of Neurochemistry. 88:81-81. 2004
- Phosphorylation Activity in the Alzheimer's Disease and Normal Brain is Modulated by Microtubule-Associated Protein, Tau in Vitro.. Journal of Alzheimer's disease : JAD. 1:169-182. 1999
- Alterations in the neurofilament cytoskeleton of dorsal root ganglia neurons consequent to microinjection of cdk5/p35. Molecular Biology of the Cell. 8:1614-1614. 1997
- Phosphorylation of human high molecular weight neurofilament protein (hNF-H) by neuronal cyclin-dependent kinase 5 (cdk5).. Brain Research. 765:259-266. 1997
- Inhibition of neuronal cyclin-dependent kinase-5 by staurosporine and purine analogs is independent of activation by Munc-18.. Neurochemical Research. 21:629-636. 1996
- A multimeric kinase-cytoskeletal complex associates with Munc-18/P67 in rat brain. Journal of Neurochemistry. 66:S64-S64. 1996
- CHARACTERIZATION OF CYCLIN-DEPENDENT KINASE-5 FROM RAT-BRAIN. Molecular Biology of the Cell. 6:1407-1407. 1995
- NEURONAL CYCLIN-DEPENDENT KINASE-5 IS INHIBITED BY STAUROSPORINE AND OLOMOUCINE. Molecular Biology of the Cell. 6:1408-1408. 1995
- P13suc1 associates with a cdc2-like kinase in a multimeric cytoskeletal complex in squid axoplasm.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 15:6222-6229. 1995