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Publications in VIVO

Fritz-Laylin, Lillian Whitman Center Scientist, Whitman Center


To understand how diverse organisms crawl, my lab is working to precisely define mechanical modes of locomotion, and then identify the genes underlying these complex traits. We use the phylogenetic distribution of suites of conserved crawling genes to trace the evolution of these key eukaryotic behaviors, as well as to predict crawling motility in new species. Day-to-day, my lab couples comparative genomics, phylogenetics, and microscopy to generate hypotheses about cell motility, which we test in a variety of organisms and cell types, including human neutrophils, insect cells, the amoeboflagellate Naegleria gruberi, and more recently Bradiochytrium dendrobatidis, a fungal disease devastating amphibian populations world-wide. Studying a broad range of organisms allows my lab to uncover core, conserved features of cell motility, as well as discover new and unexpected behaviors of less-studied cells.

selected publications