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Echeverri, Karen Associate Scientist, Bell Center

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Our aim is to understand at the molecular and cellular level how an axolotl spinal cord can functionally repair after injury and why mammals cannot. To this end we have used transcriptional profiling to identify key differences at the miRNA level between axolotl and rat after spinal cord injury. In particular we are focusing on the differences between the rostral and caudal sides of the injury site and how the axolotl creates a permissive environment for axonal regrowth while mammals do not. We are focusing not just on the neuronal cells but also on the contribution and interaction of the other cells especially endothelial cells and skin to this repair process.

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