The Microbiome Center is an intellectual home for researchers across the University of Chicago, the Marine Biological Laboratory, and Argonne National Laboratory to advance understanding of the identity and function of microbes. The Microbiome Center supports the scientists who are investigating fundamental questions and developing new applications and tools to understand and harness the capabilities of microbial systems across different fields. The Microbiome Center capitalizes on the significant activity already occurring across our institutions and our unique capabilities to enable coordinated and collaborative research. By leveraging world-class expertise and facilities, and expanding research and learning opportunities, scientists have the opportunity to challenge new frontiers. The Center supports a dynamic research community, enables rapid translation to private and clinical sectors, and trains a new generation of scientists able to take on fundamental questions about the microbiome.