selected publications
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academic article
- Cellular, ultrastructural and molecular analyses of epidermal cell development in the planarian Schmidtea mediterranea.. Developmental Biology. 433:357-373. 2018
- To solve old problems, study new research organisms.. Developmental Biology. 433:111-114. 2018
- The miR-124 family of microRNAs is crucial for regeneration of the brain and visual system in the planarian Schmidtea mediterranea.. DEVELOPMENT. 144:3211-3223. 2017
- PHRED-1 is a divergent neurexin-1 homolog that organizes muscle fibers and patterns organs during regeneration.. Developmental Biology. 427:165-175. 2017
- Hands-On Classroom Activities for Exploring Regeneration and Stem Cell Biology with Planarians. American Biology Teacher. 79:208-223. 2017
- Embryonic origin of adult stem cells required for tissue homeostasis and regeneration.. Elife. 6. 2017
- Widespread maintenance of genome heterozygosity in Schmidtea?mediterranea.. Nat Ecol Evol. 1:19. 2016
- Head regeneration in hemichordates is not a strict recapitulation of development.. Developmental Dynamics. 245:1159-1175. 2016
- Set1 and MLL1/2 Target Distinct Sets of Functionally Different Genomic Loci In Vivo.. Cell Rep. 17:930. 2016
- Egf Signaling Directs Neoblast Repopulation by Regulating Asymmetric Cell Division in Planarians.. Developmental Cell. 38:413-429. 2016
- Pathogenic shifts in endogenous microbiota impede tissue regeneration via distinct activation of TAK1/MKK/p38.. Elife. 5. 2016
- Comparative and Transcriptome Analyses Uncover Key Aspects of Coding- and Long Noncoding RNAs in Flatworm Mitochondrial Genomes.. G3 (Bethesda). 6:1191-1200. 2016
- Set1 and MLL1/2 Target Distinct Sets of Functionally Different Genomic Loci In Vivo.. Cell Rep. 13:2741-2755. 2015
- Types or States? Cellular Dynamics and Regenerative Potential.. Trends in Cell Biology. 25:687-696. 2015
- Egr-5 is a post-mitotic regulator of planarian epidermal differentiation.. Elife. 4:e10501. 2015
- SmedGD 2.0: The Schmidtea mediterranea genome database.. Developmental Genetics Genesis: the Journal of Genetics and Development. 53:535-546. 2015
- Stem cells and fluid flow drive cyst formation in an invertebrate excretory organ.. Elife. 4. 2015
- Unravelling a can of worms.. Elife. 4. 2015
- Synaptonemal complex extension from clustered telomeres mediates full-length chromosome pairing in Schmidtea mediterranea.. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences. 111:E5159-E5168. 2014
- Selective amputation of the pharynx identifies a FoxA-dependent regeneration program in planaria.. Elife. 3:e02238. 2014
- Rethinking differentiation: stem cells, regeneration, and plasticity.. Cell. 157:110-119. 2014
- Histone modifications and regeneration in the planarian Schmidtea mediterranea.. Current topics in developmental biology. 108:71-93. 2014
- Molecular cloning and characterization of SL3: a stem cell-specific SL RNA from the planarian Schmidtea mediterranea.. Gene. 533:156-167. 2014
- Learning about loss.. Elife. 2:e00533. 2013
- On the trail of a tropical disease.. Elife. 2:e01115. 2013
- The history and enduring contributions of planarians to the study of animal regeneration.. Wiley Interdiscip Rev Dev Biol. 2:301-326. 2013
- Q&A: what is regeneration, and why look to planarians for answers?. BMC Biology. 10:88. 2012
- Amputation induces stem cell mobilization to sites of injury during planarian regeneration.. DEVELOPMENT. 139:3510-3520. 2012
- Cellular hyperproliferation and cancer as evolutionary variables.. Current Biology Current Biology. 22:R772-R778. 2012
- Planarian immobilization, partial irradiation, and tissue transplantation.. J Vis Exp. 2012
- TORC1 is required to balance cell proliferation and cell death in planarians.. Developmental Biology. 365:458-469. 2012
- Mitochondrial pathway of apoptosis is ancestral in metazoans.. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences. 109:4904-4909. 2012
- Centrosome loss in the evolution of planarians.. Molecular Biology of the Cell. 335:461-463. 2012
- The maintenance and regeneration of the planarian excretory system are regulated by EGFR signaling.. DEVELOPMENT. 138:3769-3780. 2011
- Alejandro Sánchez Alvarado: bootstrapping flatworms into the molecular age.. Journal of Cell Biology. 194:510-511. 2011
- De novo assembly and validation of planaria transcriptome by massive parallel sequencing and shotgun proteomics.. Genome research. 21:1193-1200. 2011
- Expression of secreted Wnt pathway components reveals unexpected complexity of the planarian amputation response.. Developmental Biology. 347:24-39. 2010
- Genetic cellular studies of regeneration in the planarian Schmidtea mediterranea. Developmental Biology. 344:423-423. 2010
- Cell death and tissue remodeling in planarian regeneration.. Developmental Biology. 338:76-85. 2010
- A planarian p53 homolog regulates proliferation and self-renewal in adult stem cell lineages.. DEVELOPMENT. 137:213-221. 2010
- Planarian Hh signaling regulates regeneration polarity and links Hh pathway evolution to cilia.. Science Science. 326:1406-1410. 2009
- S19-01 Planarians, stem cells, and regeneration. Mechanisms of Development. 126:S47-S47. 2009
- High-resolution profiling and discovery of planarian small RNAs.. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences. 106:11546-11551. 2009
- Developmental biology: A cellular view of regeneration.. Nature Nature. 460:39-40. 2009
- Dynamic expression of planarian Wnt genes reveals complex response to amputation. Developmental Biology. 331:504-504. 2009
- Planarians, stem cells, and regeneration. Developmental Biology. 331:393-393. 2009
- Flow cytometry methods for the study of cell-cycle parameters of planarian stem cells.. Developmental Dynamics. 238:1111-1117. 2009
- Formaldehyde-based whole-mount in situ hybridization method for planarians.. Developmental Dynamics. 238:443-450. 2009
- Gene nomenclature guidelines for the planarian Schmidtea mediterranea.. Developmental Dynamics. 237:3099-3101. 2008
- Molecular analysis of stem cells and their descendants during cell turnover and regeneration in the planarian Schmidtea mediterranea.. Cell Stem Cell. 3:327-339. 2008
- Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling.. Disease models & mechanisms. 1:131-143. 2008
- Stem cells: time to check our premises.. Cell Stem Cell. 3:25-29. 2008
- Slicing across kingdoms: regeneration in plants and animals.. Cell. 132:697-710. 2008
- Beta-catenin defines head versus tail identity during planarian regeneration and homeostasis.. Science Science. 319:323-327. 2008
- MAKER: an easy-to-use annotation pipeline designed for emerging model organism genomes.. Genome research. 18:188-196. 2008
- Regeneration, stem cells, and the evolution of tumor suppression.. Cold Spring Harb Symp Quant Biol. 73:565-572. 2008
- SmedGD: the Schmidtea mediterranea genome database.. Nucleic Acids Research. 36:D599-D606. 2008
- BMP signaling regulates the dorsal planarian midline and is needed for asymmetric regeneration.. DEVELOPMENT. 134:4043-4051. 2007
- Stem cells and the Planarian Schmidtea mediterranea.. Comptes Rendus Biologies Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie. 330:498-503. 2007
- Cell turnover and adult tissue homeostasis: from humans to planarians.. Annual Review of Genetics. 41:83-105. 2007
- Bridging the regeneration gap: genetic insights from diverse animal models.. Nature Reviews Genetics. 7:873-884. 2006
- Planarian regeneration: its end is its beginning.. Cell. 124:241-245. 2006
- SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells.. Science Science. 310:1327-1330. 2005
- Multicellularity, stem cells, and the neoblasts of the planarian Schmidtea mediterranea.. Experimental Cell Research. 306:299-308. 2005
- Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria.. Developmental Cell. 8:635-649. 2005
- Planarians.. Current Biology Current Biology. 14:R737-R738. 2004
- Regeneration and the need for simpler model organisms.. Philosophical Transactions B. 359:759-763. 2004
- Morphological and functional recovery of the planarian photosensing system during head regeneration.. Zoological Science. 21:275-283. 2004
- Fundamentals of planarian regeneration.. Annual Review of Cell and Developmental Biology. 20:725-757. 2004
- Ingestion of bacterially expressed double-stranded RNA inhibits gene expression in planarians.. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences. 100 Suppl 1:11861-11865. 2003
- The freshwater planarian Schmidtea mediterranea: embryogenesis, stem cells and regeneration.. Current Opinion in Genetics & Development. 13:438-444. 2003
- Allometric scaling and proportion regulation in the freshwater planarian Schmidtea mediterranea.. Developmental Dynamics. 226:326-333. 2003
- The Schmidtea mediterranea database as a molecular resource for studying platyhelminthes, stem cells and regeneration.. DEVELOPMENT. 129:5659-5665. 2002
- FGFR-related gene nou-darake restricts brain tissues to the head region of planarians.. Nature Nature. 419:620-624. 2002
- Identification of immunological reagents for use in the study of freshwater planarians by means of whole-mount immunofluorescence and confocal microscopy.. Developmental Genetics Genesis: the Journal of Genetics and Development. 32:293-298. 2002
- Not your father's planarian: a classic model enters the era of functional genomics.. Nature Reviews Genetics. 3:210-219. 2002
- Regeneration in the metazoans: why does it happen?. Bioessays. 22:578-590. 2000
- Bromodeoxyuridine specifically labels the regenerative stem cells of planarians.. Developmental Biology. 220:142-153. 2000
- Double-stranded RNA specifically disrupts gene expression during planarian regeneration.. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences. 96:5049-5054. 1999
- The use of planarians to dissect the molecular basis of metazoan regeneration.. Wound Repair and Regeneration. 6:413-420. 1998
- Amphibian tadpoles and planarians: Model systems for the molecular study of metazoan regeneration.. Developmental Biology.
- An RNAi screen for regeneration genes in the planarian S. mediterranea.. Developmental Biology.
- An RNAi screen for regeneration genes in the planarian, Schmidtea mediterranea.. Developmental Biology.
- Cell cycle dynamics of a stem cell population in vivo: the neoblasts of the planarian Schmidtea mediterranea.. Developmental Biology.
- Centrosome Loss in the Evolution of Planarians. Science Science.
- Chromatin architecture in the planarian Schmidtea mediterranea.. Developmental Biology.
- Developing a model system to study regeneration. Molecular Biology of the Cell.
- Functional genomic analysis of germ cell specification in planarians.. Developmental Biology.
- Functional studies of regeneration in the planarian Schmidtea mediterranea.. Developmental Biology.
- Identification of stem cell gene candidates in the planarian Schmidtea mediterranea.. Developmental Biology.
- Investigating Regeneration. Developmental Cell.
- Labeling of multipotent progenitor cells in the planarian schmidtea mediterranea.. Developmental Biology.
- Learning about loss
- Maintenance and regeneration of form and function in the planarian Schmidtea mediterranea.. Developmental Biology.
- Metazoan regeneration.. Developmental Biology.
- Molecular approaches to studying regeneration in planarians. Developmental Biology.
- Pathogenic shifts in endogenous microbiota impede tissue regeneration via distinct activation of TAK1/MKK/p38
- Pc-astakine mRNA levels decrease after both LPS injection and hemolymph withdrawals in the gastropod pest Pomacea canaliculata. Fish and Shellfish Immunology.
- Planarian regeneration: A classic problem enters the era of functional genomics.. Developmental Biology.
- Planarian regeneration: Revisiting a classic problem using modern methodologies.. Developmental Biology.
- Reply: Bridging the regeneration gap: insights from echinoderm models. Nature Reviews Genetics.
- Stem cell and regeneration regulators in the planarian Schmidtea mediterranea.. Developmental Biology.
- Stem cell regulation in the planarian Schmidtea mediterranea. Molecular Biology of the Cell.
- Stem cells, regeneration and allometry in the planarian schmidtea mediterranea.. Developmental Biology.
- Stem cells, regeneration and the developmental plasticity of planarians. American Zoologist.
- Systematic analysis of cell signaling during planarian tissue regeneration, remodeling & homeostasis. FASEB Journal Federation proceedings.
- Tissue regulation. Biofutur.
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conference paper
- Head Regeneration in a Stem Deuterostome. American Zoologist.
- Interplay of the Microbiome and Innate Immune System in Tissue Regeneration.. Molecular Biology of the Cell.
- Regulation of stem cell repopulation in the planarian Schmidtea mediterranea.. Molecular Biology of the Cell.