Publications in VIVO

Co-author Network

Sanchez Alvarado, Alejandro MBL Fellow, Bell Center

Positions

Investigator, Howard Hughes Medical Institute 2005 -
Investigator, Stowers Institute for Medical Research 2011 -
MBL Fellow, Bell Center , Marine Biological Laboratory 2016 -

Alejandro Sánchez Alvarado has established a powerful new model system to study the molecular mechanics of regeneration, using the freshwater flatworm Schmidtea mediterranea. Sánchez Alvarado's lab has developed the molecular tools needed to reveal how regeneration works in this flatworm.

Publications
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selected publications

academic article
- Prospectively Isolated Tetraspanin+ Neoblasts Are Adult Pluripotent Stem Cells Underlying Planaria Regeneration.. Cell. 173:1593-1608.e20. 2018
- Challenging Stem Cells. Cell. 173:1063-1065. 2018
- An adaptable chromosome preparation methodology for use in invertebrate research organisms.. BMC Biology. 16:25. 2018
- Cellular, ultrastructural and molecular analyses of epidermal cell development in the planarian Schmidtea mediterranea.. Developmental Biology. 433:357-373. 2018
- To solve old problems, study new research organisms.. Developmental Biology. 433:111-114. 2018
- Culturing Planarians in the Laboratory.. Methods in molecular biology (Clifton, N.J.). 1774:241-258. 2018
- Planarian High Molecular Weight DNA Isolation by Spooling.. Methods in molecular biology (Clifton, N.J.). 1774:277-284. 2018
- Planarians and the History of Animal Regeneration: Paradigm Shifts and Key Concepts in Biology.. Methods in molecular biology (Clifton, N.J.). 1774:207-239. 2018
- Systemic RNA Interference in Planarians by Feeding of dsRNA Containing Bacteria.. Methods in molecular biology (Clifton, N.J.). 1774:445-454. 2018
- Whole-Mount BrdU Staining with Fluorescence In Situ Hybridization in Planarians.. Methods in molecular biology (Clifton, N.J.). 1774:423-434. 2018
- Investigating Regeneration. Developmental Cell. 43:373-376. 2017
- The miR-124 family of microRNAs is crucial for regeneration of the brain and visual system in the planarian Schmidtea mediterranea.. DEVELOPMENT. 144:3211-3223. 2017
- PHRED-1 is a divergent neurexin-1 homolog that organizes muscle fibers and patterns organs during regeneration.. Developmental Biology. 427:165-175. 2017
- Hands-On Classroom Activities for Exploring Regeneration and Stem Cell Biology with Planarians. American Biology Teacher. 79:208-223. 2017
- Embryonic origin of adult stem cells required for tissue homeostasis and regeneration.. ELIFE. 6. 2017
- Widespread maintenance of genome heterozygosity in Schmidtea?mediterranea.. Nat Ecol Evol. 1:19. 2016
- Head regeneration in hemichordates is not a strict recapitulation of development.. Developmental Dynamics. 245:1159-1175. 2016
- Set1 and MLL1/2 Target Distinct Sets of Functionally Different Genomic Loci In Vivo.. Cell Rep. 17:930. 2016
- Egf Signaling Directs Neoblast Repopulation by Regulating Asymmetric Cell Division in Planarians.. Developmental Cell. 38:413-429. 2016
- Pathogenic shifts in endogenous microbiota impede tissue regeneration via distinct activation of TAK1/MKK/p38.. ELIFE. 5. 2016
- Comparative and Transcriptome Analyses Uncover Key Aspects of Coding- and Long Noncoding RNAs in Flatworm Mitochondrial Genomes.. G3 (Bethesda). 6:1191-1200. 2016
- Set1 and MLL1/2 Target Distinct Sets of Functionally Different Genomic Loci In Vivo.. Cell Rep. 13:2741-2755. 2015
- Types or States? Cellular Dynamics and Regenerative Potential.. Trends in Cell Biology. 25:687-696. 2015
- Egr-5 is a post-mitotic regulator of planarian epidermal differentiation.. ELIFE. 4:e10501. 2015
- SmedGD 2.0: The Schmidtea mediterranea genome database.. Developmental Genetics Genesis: the Journal of Genetics and Development. 53:535-546. 2015
- Stem cells and fluid flow drive cyst formation in an invertebrate excretory organ.. ELIFE. 4. 2015
- Unravelling a can of worms.. ELIFE. 4. 2015
- Synaptonemal complex extension from clustered telomeres mediates full-length chromosome pairing in Schmidtea mediterranea.. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences. 111:E5159-E5168. 2014
- Selective amputation of the pharynx identifies a FoxA-dependent regeneration program in planaria.. ELIFE. 3:e02238. 2014
- Rethinking differentiation: stem cells, regeneration, and plasticity.. Cell. 157:110-119. 2014
- Histone modifications and regeneration in the planarian Schmidtea mediterranea.. Current topics in developmental biology. 108:71-93. 2014
- Molecular cloning and characterization of SL3: a stem cell-specific SL RNA from the planarian Schmidtea mediterranea.. Gene. 533:156-167. 2014
- Learning about loss.. ELIFE. 2:e00533. 2013
- On the trail of a tropical disease.. ELIFE. 2:e01115. 2013
- The history and enduring contributions of planarians to the study of animal regeneration.. Wiley Interdiscip Rev Dev Biol. 2:301-326. 2013
- Q&A: what is regeneration, and why look to planarians for answers?. BMC Biology. 10:88. 2012
- Amputation induces stem cell mobilization to sites of injury during planarian regeneration.. DEVELOPMENT. 139:3510-3520. 2012
- Cellular hyperproliferation and cancer as evolutionary variables.. Current Biology Current Biology. 22:R772-R778. 2012
- Planarian immobilization, partial irradiation, and tissue transplantation.. J Vis Exp. 2012
- TORC1 is required to balance cell proliferation and cell death in planarians.. Developmental Biology. 365:458-469. 2012
- Mitochondrial pathway of apoptosis is ancestral in metazoans.. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences. 109:4904-4909. 2012
- Centrosome loss in the evolution of planarians.. Molecular Biology of the Cell. 335:461-463. 2012
- The maintenance and regeneration of the planarian excretory system are regulated by EGFR signaling.. DEVELOPMENT. 138:3769-3780. 2011
- Alejandro Sánchez Alvarado: bootstrapping flatworms into the molecular age.. Journal of Cell Biology. 194:510-511. 2011
- De novo assembly and validation of planaria transcriptome by massive parallel sequencing and shotgun proteomics.. Genome research. 21:1193-1200. 2011
- Expression of secreted Wnt pathway components reveals unexpected complexity of the planarian amputation response.. Developmental Biology. 347:24-39. 2010
- Genetic cellular studies of regeneration in the planarian Schmidtea mediterranea. Developmental Biology. 344:423-423. 2010
- Cell death and tissue remodeling in planarian regeneration.. Developmental Biology. 338:76-85. 2010
- A planarian p53 homolog regulates proliferation and self-renewal in adult stem cell lineages.. DEVELOPMENT. 137:213-221. 2010
- Planarian Hh signaling regulates regeneration polarity and links Hh pathway evolution to cilia.. Science Science. 326:1406-1410. 2009
- S19-01 Planarians, stem cells, and regeneration. Mechanisms of Development. 126:S47-S47. 2009
- High-resolution profiling and discovery of planarian small RNAs.. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences. 106:11546-11551. 2009
- Developmental biology: A cellular view of regeneration.. Nature Nature. 460:39-40. 2009
- Dynamic expression of planarian Wnt genes reveals complex response to amputation. Developmental Biology. 331:504-504. 2009
- Planarians, stem cells, and regeneration. Developmental Biology. 331:393-393. 2009
- Flow cytometry methods for the study of cell-cycle parameters of planarian stem cells.. Developmental Dynamics. 238:1111-1117. 2009
- Formaldehyde-based whole-mount in situ hybridization method for planarians.. Developmental Dynamics. 238:443-450. 2009
- Gene nomenclature guidelines for the planarian Schmidtea mediterranea.. Developmental Dynamics. 237:3099-3101. 2008
- Molecular analysis of stem cells and their descendants during cell turnover and regeneration in the planarian Schmidtea mediterranea.. Cell Stem Cell. 3:327-339. 2008
- Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling.. Disease models & mechanisms. 1:131-143. 2008
- Stem cells: time to check our premises.. Cell Stem Cell. 3:25-29. 2008
- Slicing across kingdoms: regeneration in plants and animals.. Cell. 132:697-710. 2008
- Beta-catenin defines head versus tail identity during planarian regeneration and homeostasis.. Science Science. 319:323-327. 2008
- MAKER: an easy-to-use annotation pipeline designed for emerging model organism genomes.. Genome research. 18:188-196. 2008
- Regeneration, stem cells, and the evolution of tumor suppression.. Cold Spring Harb Symp Quant Biol. 73:565-572. 2008
- SmedGD: the Schmidtea mediterranea genome database.. Nucleic Acids Research. 36:D599-D606. 2008
- BMP signaling regulates the dorsal planarian midline and is needed for asymmetric regeneration.. DEVELOPMENT. 134:4043-4051. 2007
- Stem cells and the Planarian Schmidtea mediterranea.. Comptes Rendus Biologies Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie. 330:498-503. 2007
- Cell turnover and adult tissue homeostasis: from humans to planarians.. Annual Review of Genetics. 41:83-105. 2007
- Bridging the regeneration gap: genetic insights from diverse animal models.. Nature Reviews Genetics. 7:873-884. 2006
- Planarian regeneration: its end is its beginning.. Cell. 124:241-245. 2006
- SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells.. Science Science. 310:1327-1330. 2005
- Multicellularity, stem cells, and the neoblasts of the planarian Schmidtea mediterranea.. Experimental Cell Research. 306:299-308. 2005
- Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria.. Developmental Cell. 8:635-649. 2005
- Planarians.. Current Biology Current Biology. 14:R737-R738. 2004
- Regeneration and the need for simpler model organisms.. Philosophical Transactions B. 359:759-763. 2004
- Morphological and functional recovery of the planarian photosensing system during head regeneration.. Zoological Science. 21:275-283. 2004
- Fundamentals of planarian regeneration.. Annual Review of Cell and Developmental Biology. 20:725-757. 2004
- Ingestion of bacterially expressed double-stranded RNA inhibits gene expression in planarians.. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences. 100 Suppl 1:11861-11865. 2003
- The freshwater planarian Schmidtea mediterranea: embryogenesis, stem cells and regeneration.. Current Opinion in Genetics & Development. 13:438-444. 2003
- Allometric scaling and proportion regulation in the freshwater planarian Schmidtea mediterranea.. Developmental Dynamics. 226:326-333. 2003
- The Schmidtea mediterranea database as a molecular resource for studying platyhelminthes, stem cells and regeneration.. DEVELOPMENT. 129:5659-5665. 2002
- FGFR-related gene nou-darake restricts brain tissues to the head region of planarians.. Nature Nature. 419:620-624. 2002
- Identification of immunological reagents for use in the study of freshwater planarians by means of whole-mount immunofluorescence and confocal microscopy.. Developmental Genetics Genesis: the Journal of Genetics and Development. 32:293-298. 2002
- Not your father's planarian: a classic model enters the era of functional genomics.. Nature Reviews Genetics. 3:210-219. 2002
- Regeneration in the metazoans: why does it happen?. Bioessays. 22:578-590. 2000
- Bromodeoxyuridine specifically labels the regenerative stem cells of planarians.. Developmental Biology. 220:142-153. 2000
- Double-stranded RNA specifically disrupts gene expression during planarian regeneration.. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences. 96:5049-5054. 1999
- The use of planarians to dissect the molecular basis of metazoan regeneration.. Wound Repair and Regeneration. 6:413-420. 1998
- Amphibian tadpoles and planarians: Model systems for the molecular study of metazoan regeneration.. Developmental Biology.
- An RNAi screen for regeneration genes in the planarian S. mediterranea.. Developmental Biology.
- An RNAi screen for regeneration genes in the planarian, Schmidtea mediterranea.. Developmental Biology.
- Cell cycle dynamics of a stem cell population in vivo: the neoblasts of the planarian Schmidtea mediterranea.. Developmental Biology.
- Centrosome Loss in the Evolution of Planarians. Science Science.
- Chromatin architecture in the planarian Schmidtea mediterranea.. Developmental Biology.
- Developing a model system to study regeneration. Molecular Biology of the Cell.
- Dr. Panagiotis (Takis) Tsonis: A man for all seasons In Memoriam. Developmental Biology.
- Functional genomic analysis of germ cell specification in planarians.. Developmental Biology.
- Functional studies of regeneration in the planarian Schmidtea mediterranea.. Developmental Biology.
- Identification of stem cell gene candidates in the planarian Schmidtea mediterranea.. Developmental Biology.
- Labeling of multipotent progenitor cells in the planarian schmidtea mediterranea.. Developmental Biology.
- Learning about loss
- Maintenance and regeneration of form and function in the planarian Schmidtea mediterranea.. Developmental Biology.
- Metazoan regeneration.. Developmental Biology.
- Molecular approaches to studying regeneration in planarians. Developmental Biology.
- Pathogenic shifts in endogenous microbiota impede tissue regeneration via distinct activation of TAK1/MKK/p38
- Pc-astakine mRNA levels decrease after both LPS injection and hemolymph withdrawals in the gastropod pest Pomacea canaliculata. Fish and Shellfish Immunology.
- Planarian regeneration: A classic problem enters the era of functional genomics.. Developmental Biology.
- Planarian regeneration: Revisiting a classic problem using modern methodologies.. Developmental Biology.
- Reply: Bridging the regeneration gap: insights from echinoderm models. Nature Reviews Genetics.
- Stem cell and regeneration regulators in the planarian Schmidtea mediterranea.. Developmental Biology.
- Stem cell regulation in the planarian Schmidtea mediterranea. Molecular Biology of the Cell.
- Stem cells, regeneration and allometry in the planarian schmidtea mediterranea.. Developmental Biology.
- Stem cells, regeneration and the developmental plasticity of planarians. American Zoologist.
- Systematic analysis of cell signaling during planarian tissue regeneration, remodeling & homeostasis. FASEB Journal Federation proceedings.
- Tissue regulation. Biofutur.
conference paper
- Complete Regeneration of a Camera-type Eye in the Research Organism Pomacea canaliculata. FASEB Journal Federation proceedings.
- Head Regeneration in a Stem Deuterostome. American Zoologist.
- Interplay of the Microbiome and Innate Immune System in Tissue Regeneration.. Molecular Biology of the Cell.
- Regulation of stem cell repopulation in the planarian Schmidtea mediterranea.. Molecular Biology of the Cell.